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ea0089b16 | Basic Science | NANETS2022

[212Pb]PSC-PEG2-TOC Therapy for NET Leads to Complete Responses in Mice Bearing SSTR2 Positive Tumors - Comparison to [177Lu]DOTATATE in a Preclinical Model

Schultz Michael K. , Liu Dijie , Li Mengshi , Cagle Brianna S. , Dai Zhiming , Lee Dongyoul , Orcutt Kelly , Sagastume Edwin , Baumhover Nicholas J. , Vance Ivy , Hedt Amos , Menda Yusuf , Johnson Frances L.

Background: Peptide-based targeted alpha-particle radiotherapy has emerged as a promising approach to cancer treatment. 203Pb/212Pb is the only elementally identical isotope pair for this application. Tyr3-Octreotide (TOC) peptide ligands targeting SSTR2 have been widely investigated preclinically and clinically. [177Lu]DOTATATE was approved by the US FDA to treat patients with gastroenteropancreatic neuroendocrine tumors. However, t...

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Endocrine Abstracts

[212Pb]PSC-PEG2-TOC Therapy for NET Leads to Complete Responses in Mice Bearing SSTR2 Positive Tumors - Comparison to [177Lu]DOTATATE in a Preclinical Model

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